Changes in Glucose Metabolism with Aging

The Effects of Aging on Glucose Metabolism

Type 2 diabetes mellitus is the most common chronic metabolic disease/disorder in the elderly. The prevalence and incidence of impaired glucose tolerance and diabetes mellitus increase with aging. In Taiwan, the prevalence of diabetes mellitus increases with age and is approximately 20% in those aged 65 years or older. The incidence of diabetes mellitus is also increasing in Taiwan. In an epide...

Targeting glucose metabolism for healthy aging

Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the ability to target the aging process can facilitate improved healthspan and potentially lifespan. Lack of adequate glucoregulatory control remains a recurrent theme accompanying aging and chronic disease, while numerous longevity interventions result in maintenance of glucoregulatory control. In this review...

Overview of glucose metabolism and aging.

Nutrition and aging: changes in the regulation of energy metabolism with aging.

Changes in energy regulation occur during normal aging and contribute to the common phenomenon of weight and fat losses late in life. This review synthesizes data on aging-related changes in energy intake and energy expenditure and on the regulation of energy intake and expenditure. The ability of older adults to accurately regulate energy intake is impaired, with a number of possible explanati...

Serotonin modulation of cerebral glucose metabolism in normal aging.

Age-related alterations in serotonin function may increase the vulnerability to psychiatric and neurodegenerative disorders in late life. The neuroendocrine and cerebral metabolic response to the acute administration of the selective serotonin reuptake inhibitor, citalopram (40mg, IV), was measured in 17 normal control subjects using positron emission tomography (PET) to evaluate changes in ser...